Aging and skin renewal are both continuous processes—neither happens overnight. Modern aesthetic medicine now recognizes that the most effective rejuvenation doesn’t rely on artificial volume but on the body’s natural healing process. Among the most studied advances in regenerative medicine, Platelet-Derived Growth Factor (PDGF) stands out for its ability to renew skin from the cellular level outward, stimulating the very mechanisms that maintain elasticity, hydration, and tone.
At Trubella Medspa and Aesthetics in Dedham, PDGF therapy is part of a refined approach to skin rejuvenation, backed by science and designed for patients who value long-term results. Our expert team offers PDGF as both a standalone treatment and a complement to our other skin rejuvenation procedures for comprehensive improvement in skin health and texture.
Platelet-Derived Growth Factor (PDGF) is one of several growth factors found naturally in the body’s platelets. When platelets are activated, they release PDGF along with other regenerative messengers like epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF), all of which help restore the skin’s structural integrity. It triggers cell growth, tissue repair, and the formation of new blood vessels, critical elements of healthy skin and wound healing.
In aesthetics, PDGF is isolated from a patient’s blood, a process similar to PRP therapy, and then applied or injected into targeted areas. Once in the deeper layers of the skin, PDGF stimulates dermal fibroblasts and smooth muscle cells, promoting collagen production, elastin formation, and overall tissue regeneration. The result is smoother, healthier skin supported by renewed strength from within.
PDGF strengthens the skin from the inside out. It restores the structure that gives skin its firmness and tone while improving how it holds moisture and heals itself. Over time, the surface looks smoother, color more even, and texture more consistent.
Key benefits include:
PDGF is great for patients looking to keep their skin in good condition. The treatment works across skin types and ages, addressing early signs of aging, texture issues, or general dullness.
Candidates often include those noticing early signs of uneven texture, dry skin, or mild skin laxity. It can also be used to aid tissue repair in areas affected by acne scars, sun damage, or fine lines. During consultation, your Trubella specialist will evaluate your overall health, skin quality, and aesthetic goals to determine if PDGF is the right choice or if it should be paired with another treatment such as platelet-rich plasma (PRP) or microneedling for enhanced results.
Hair
Platelet Derived Growth Factor is a regenerative treatment known for its healing power; it delivers a high concentration of growth factors directly to the dormant hair follicles and stimulates new hair growth; PDGF is applied to the scalp after an RF microneedling treatment which is purchased separately. A package of 3-6 treatments are needed for desired outcome microneedling treatment.
Under Eye Hollowness and Dark Circles
Platelet Derived Growth Factor is a regenerative treatment known for its healing power; it is injected under the eyes and delivers a high concentration of growth factors which reduce dark circles, hollowness and wrinkles; a package of 3 treatments are needed for desired results.
Post Treatment Healing
Applying Platelet-Derived Growth Factor (PDGF) immediately after microneedling maximizes skin rejuvenation by penetrating microchannels to stimulate collagen and elastin production. This combination accelerates healing, reduces downtime, and enhances results for firmer, smoother skin.
Platelet Rich Plasma (PRP) is a regenerative treatment known for healing power and the ability to treat scars, stimulate hair growth, increase blood flow and stimulate the production of collagen for sexual wellness and rejuvenation; a small amount of the patients' blood is drawn and spun to separate the platelet rich plasma and it is then injected into desired area; a package of 3-6 treatments is needed for desried outcome.
Exosomes are tiny membrane-bound vesicles which facilitate cell to cell communication and deliver instructions to calm inflammation, repair damaged tissue and increase collagen and elastin production. Exosomes are applied post microneedling as they can deeply penetrate the micro-channels created during the treatment and accelerate healing and collagen and elastin production.
A coenzyme which restores cellular function, repairs DNA, and boosts mitochondrial energy production. By bypassing the digestive system, it directly fuels sirituins, proteins responsible for longevity and cell repair which combat aging, reduce inflammation, and enhance cognitive and physical performance. NAD+ can be delivered via iontophoresis, intramuscular injection or IV Therapy.
At Trubella Medspa and Aesthetics, every treatment begins with a consultation. Your provider will review your medical history, discuss your skin concerns, and evaluate your skin condition to design a plan tailored to your goals.
Before your appointment, you might be asked to skip blood-thinning supplements, limit alcohol or caffeine the day before, and arrive with a clean face. These simple steps reduce redness and help your skin absorb the treatment more effectively. The goal is to set up the best conditions for your skin to respond and heal quickly.
The treatment begins with a small blood draw, similar to what’s done for PRP therapy. The sample is processed to separate a higher concentration of platelets containing alpha granules, which release PDGF and other growth factors upon activation.
Your provider then applies or injects the prepared PDGF serum into the targeted treatment area—either topically (following microneedling) or through direct PDGF injections. In some cases, it’s layered with hyaluronic acid or used alongside mesenchymal stem cell–derived serums for advanced cellular regeneration.
The entire procedure typically takes under an hour. Most patients describe it as comfortable thanks to a gentle numbing agent applied beforehand.
There’s little downtime with PDGF. Some redness or faint swelling can show up after treatment, especially if it’s paired with microneedling, but it usually fades within a day. Keeping the skin clean and hydrated helps it recover smoothly. Avoid exfoliating or heavy products for a short while, then return to your regular routine. Makeup can usually be worn the next day.
Following your provider’s aftercare plan helps sustain the regenerative process and encourages continued collagen production for weeks afterward.
Because PDGF works at the cellular level, results appear progressively. Most patients notice improved skin tone and texture within three to four weeks, with continued enhancement as collagen and elastin fibers strengthen. Depending on your skin concerns and overall treatment plan, results can last several months, often extended through maintenance sessions or combination therapies.
Pairing PDGF with Microneedling elevates collagen remodeling and speeds recovery. The tiny needles create microchannels that allow platelet-derived growth factor to reach the deeper layers of skin, amplifying the repair response.
Applied after a Facial, PDGF helps the skin hold onto moisture longer and extends the post-treatment glow. It supports gentle cell renewal without irritation.
Used alongside Medical-Grade Skincare, PDGF improves how the skin absorbs active ingredients and reinforces the barrier that keeps moisture in.
Paired with a Chemical Peel, PDGF helps the skin heal evenly, reducing post-peel redness and revealing a clearer, steadier tone.
The cost of PDGF therapy depends on the treatment area, number of sessions, and whether it’s combined with other procedures. During your consultation, we’ll provide a detailed quote so you can make an informed decision.
Platelet-Derived Growth Factor (PDGF) helps the body do what it’s already built to do: repair, rebuild, and renew. Call 617-872-5877 to schedule your consultation at Trubella Medspa and Aesthetics in Dedham and learn how PDGF can fit into your broader skin plan.
Yes. PDGF is FDA-approved for various clinical and cosmetic uses, derived from your own blood, and considered safe for all skin types.
While both come from platelets, PDGF isolates a specific derived growth factor (PDGF-BB) responsible for cell growth, blood vessel formation, and tissue repair, making it more concentrated and targeted than standard PRP therapy.
Most patients see initial brightness and smoother skin within several weeks, with continued improvement as collagen production and tissue regeneration progress.
Yes. By rebuilding the extracellular matrix, PDGF improves skin texture, helping fade acne scars and restore a smoother complexion.
Only minimal downtime—mild redness or swelling may occur briefly, but most clients resume regular activities the same day.
